Author: Bob Brensel | President, Pharmacist | ScriptWorks
Bob Brensel, RPh, earned his Pharmacy Degree at University of the Pacific in Stockton, California in 1980. Former California Pharmacists Association’s Award Winner for Recognition of Outstanding Achievement in Compounding Pharmacy. Read More →
Neurological Health in California: The Potential of Compounded Methylcobalamin (Synapsin™) RG3 Nasal Spray
Due to recurrent wildfires, California residents face unique environmental health challenges. Among these lasting effects could be cognitive function and overall neurological well-being. Conditions such as neurological inflammation, dementia, chronic fatigue syndrome (CFS), and other neurodegenerative diseases continue to develop.
Recent advancements in compounding have introduced innovative formulations like ScriptWorks’ Compounded Methylcobalamin (Synapsin™) RG3 Nicotinamide Riboside Nasal Spray, which may offer support for these issues.
Understanding Methylcobalamin (Synapsin™) RG3 Nasal Spray
Methylcobalamin (Synapsin™) RG3 is a blend that combines methylcobalamin (the bioactive form of vitamin B12), ginsenoside RG3 (derived from Panax ginseng), and nicotinamide riboside, a form of vitamin B3.
The nasal spray delivery method ensures that these compounds are efficiently absorbed, potentially offering benefits for individuals experiencing cognitive challenges.
The Role of Each Component: What Research Indicates
1. Ginsenoside RG3: Extracted from Panax ginseng, RG3 has been studied for its neuroprotective properties.
“Ginsenoside Rg3 was effective in reducing neuroinflammation and damage in hippocampal neurons.”
Laboratory studies suggest that RG3 may support healthy microglial activity and neuronal function, which are crucial for maintaining cognitive health.
2. Nicotinamide Riboside (NR): As a form of vitamin B3, NR serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy production.
“The current research demonstrates that supplementing with NR can effectively increase NAD+ levels, improve cortical blood oxygen saturation, enhance cognitive function, and reduce neuropathological damage.”
Research indicates that NR administration may help maintain healthy NAD+ levels, supporting neuronal health and potentially offering neuroprotective effects.
3. Methylcobalamin: This active form of vitamin B12 is vital for nerve cell function and DNA synthesis.
“Methylcobalamin is an active form of vitamin B12 that helps in synthesis of methionine and S-adenosylmethionine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis.”
Methylcobalamin supports the maintenance of the myelin sheath, which protects nerve fibers, and aids in neurotransmitter synthesis, essential for cognitive processes.
Potential Applications in Neurological Conditions
Compounded Methylcobalamin (Synapsin™) RG3 Nicotinamide Riboside Nasal Spray may offer support in managing various neurological conditions:
- Dementia and Cognitive Decline: Age-related cognitive decline and neurodegenerative diseases like Alzheimer’s are significant concerns. The components of Methylcobalamin (Synapsin™) RG3 have been studied for their potential neuroprotective effects, which may support cognitive function.
- Chronic Fatigue Syndrome (CFS): CFS is characterized by persistent fatigue not alleviated by rest. The ingredients in Synapsin™ may help support mitochondrial function and energy production, potentially addressing some aspects of fatigue.
- Neurological Inflammation: Inflammation of neural tissues can lead to various cognitive and neurological symptoms. Ginsenoside RG3 has been reported to support neuroprotection by helping to maintain healthy microglial activity and neuronal function.
Why Consider Nasal Spray for Compounded Methylcobalamin (Synapsin™)?
The nasal delivery route offers a direct pathway to the central nervous system, potentially allowing for more efficient absorption of therapeutic agents. This method may be particularly beneficial for individuals with gastrointestinal issues that impede oral absorption or for those seeking a non-invasive alternative to injections.
ScriptWorks Pharmacy: California’s Partner in Neurological Health
At ScriptWorks Pharmacy, located in Walnut Creek, California, we specialize in compounding personalized medications tailored to meet the unique needs of CA patients, statewide. Our compounded Methylcobalamin (Synapsin™) RG3 Nasal Spray is prepared with the highest standards of quality and care, ensuring that you receive a formulation designed to support your neurological health.
PCAB Accreditation: Highest Standard in Quality
Since 2003, the pharmacists and technicians at ScriptWorks have been formulating and preparing customized medicines for people and pets. We work closely with healthcare providers, veterinarians, and other medical professionals to develop customized medicine solutions.
We are a PCAB-accredited pharmacy, which means an independent board of auditors and inspectors has certified our procedures and policies in every aspect of compounding. Learn more about PCAB accreditation.
Who Prescribes Methylcobalamin (Synapsin™) RG3 Nasal Spray?
Methylcobalamin (Synapsin™) RG3 Nasal Spray is typically prescribed by California healthcare practitioners who focus on neurological health, functional medicine, and integrative approaches to patient care. These professionals recognize the potential benefits of compounded formulations for supporting cognitive function, nerve health, and overall neurological well-being. They know to trust ScriptWorks.
- Neurologists – Specialists in brain and nervous system disorders who may incorporate compounded formulations as part of a comprehensive approach to cognitive support, neuroinflammation, or neurodegenerative conditions.
- Functional Medicine Practitioners – Doctors and healthcare professionals who take a root-cause approach to health and may recommend Methylcobalamin (Synapsin™) RG3 as part of a personalized wellness plan for cognitive function, chronic fatigue, or neurological health.
- Integrative Medicine Doctors – Physicians who blend conventional and alternative medications to support brain health and neuroprotection.
- Naturopathic Doctors (NDs) – NDs often use evidence-informed natural therapies and compounded medications to support neurological health and energy metabolism.
- Anti-Aging and Regenerative Medicine Specialists – Practitioners focused on optimizing cognitive longevity and cellular health may incorporate Methylcobalamin (Synapsin™) RG3 to support NAD+ levels and mitochondrial function.
- Chronic Fatigue and Fibromyalgia Specialists – Given its potential role in supporting energy production and neurological function, some practitioners addressing CFS, fibromyalgia, and related conditions may prescribe this compounded nasal spray.
- Primary Care Physicians (PCPs) and Internal Medicine Doctors – Some PCPs with a focus on integrative and preventive care may prescribe Methylcobalamin (Synapsin™) RG3 for patients experiencing brain fog, fatigue, or neurological concerns.
- Pain Management and Rehabilitation Specialists – Physicians addressing nerve-related pain or recovery from neurological injury may consider this formulation as part of a broader care plan.
We invite healthcare providers to consider the potential benefits of compounded Methylcobalamin (Synapsin™) RG3 nasal spray for patients experiencing cognitive challenges. Our pharmacy is equipped to collaborate closely with practitioners to develop customized formulations that align with specific therapeutic goals. Let’s work together to provide patients with innovative options.
Patients: Take the Next Step
If you or a loved one is facing cognitive health challenges and are interested in exploring compounded solutions, we encourage you to contact your practitioner to see if Methylcobalamin (Synapsin™) RG3 may be the right fit. Our team is dedicated to providing personalized care to support neurological health.
Reach out to us today to learn more about how compounded Methylcobalamin (Synapsin™) RG3 nasal spray may be a valuable addition to your health regimen.
References
DiSabato, D. J., Quan, N., & Godbout, J. P. (2016). Neuroinflammation: the devil is in the details. Journal of neurochemistry, 139, 136-153. Link
Feng, H., Xue, M., Deng, H., Cheng, S., Hu, Y., & Zhou, C. (2022). Ginsenoside and its therapeutic potential for cognitive impairment. Biomolecules, 12(9), 1310. Link
Gupta, J. K., & Sana, Q. S. (2015). Potential benefits of methylcobalamin: A review. Austin J Pharmacol Ther, 3(3), 1076. Link
Jia, Y., Wang, H., Fan, W., Lv, J., Niu, Q., Zhu, R., & Zhang, Q. (2024). Effects of polyphenol-rich seed foods on lipid and inflammatory markers in patients with coronary heart disease: a systematic review. Frontiers in Nutrition, 11, 1493410. Link
Liu, X., Gu, J., Wang, C., Peng, M., Zhou, J., Fei, X., … & Li, B. (2024). Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell Cycle, 23(6), 662-681. Link
McEwen, B., & Martin, T. (2023). Chronic fatigue syndrome: The potential of nutritional medicine. Journal of the Australian Traditional-Medicine Society, 29(3), 124-131. Link
Orr, M. E., Kotkowski, E., Ramirez, P., Bair-Kelps, D., Liu, Q., Brenner, C., … & Powers, B. (2024). A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. Geroscience, 46(1), 665-682. Link
Vita, J. A. (2005). Polyphenols and cardiovascular disease: effects on endothelial and platelet function. The American journal of clinical nutrition, 81(1), 292S-297S. Link
Wang, L., Peng, T., Deng, J., Gao, W., Wang, H., Luo, O. J., & Chen, G. (2024). Nicotinamide riboside alleviates brain dysfunction induced by chronic cerebral hypoperfusion via protecting mitochondria. Biochemical Pharmacology, 225, 116272. Link