Author: Bob Brensel | President, Pharmacist | ScriptWorks
Bob Brensel, RPh, earned his Pharmacy Degree at University of the Pacific in Stockton, California in 1980. Former California Pharmacists Association’s Award Winner for Recognition of Outstanding Achievement in Compounding Pharmacy. Read More →
Healthcare providers all over the country commonly prescribe doxycycline suspension or topical gel for bacterial infections, particularly for dental and periodontal concerns. In California, where patients prioritize high-quality care, compounded doxycycline offers options to support the individual needs of dental patients. ScriptWorks Pharmacy, located in Walnut Creek, CA, provides dye-free doxycycline suspension or gel, customized with Perio Gel™, which contains hydrogen peroxide, as a tailored formulation to support individuals at risk for gum disease and oral infections.
Understanding Doxycycline for Dental Health Application
Doxycycline is a broad-spectrum antibiotic frequently used to address bacterial infections, including those affecting oral health. When formulated as a liquid suspension or topical gel it provides a targeted approach directly to the gums.
Researchers found that Doxycycline-coated surfaces reduced both biofilm formation and planktonic bacterial growth, particularly against Staphylococcus epidermidis, a common organism associated with dental implant-related infections.
“Biofilm formation on the Doxycycline-coated surface was significantly inhibited. This is important because steady-state biofilm is difficult to eradicate after formation as it is more resistant to antibiotics than planktonic bacteria and requires up to 250 times greater concentration of an antibiotic agent to inhibit the growth compared to the same strains grown planktonically.”
Source: Biomed
Oral health plays a crucial role in overall well-being, as bacterial infections in the mouth that are left alone can lead to severe complications. Periodontal infections, in particular, can contribute to gum disease, requiring antibiotic support to manage bacterial growth and promote healing.
Providers often prescribe doxycycline suspension or gel for oral health conditions where bacterial management is necessary. This is especially relevant for patients undergoing dental procedures, such as tooth extractions or gum procedures, where infection prevention is essential. The liquid formulation enhances ease of administration, particularly for individuals who struggle with solid medications.
Proper management of bacterial growth in the mouth may alleviate discomfort and prevent more severe dental complications. For individuals with chronic dental concerns, doxycycline may be an integral part of a comprehensive oral health plan that includes professional dental care, good oral hygiene practices, and appropriate nutritional support.
SCRIPTWORKS IS A PERIO PROTECT™ PARTNER.
Gum disease is caused by a bacterial infection that is hidden below your gums. Dental cleanings may address the bacteria, but when you return home, the cycle often continues. Bacterial cells grow back in just hours after a cleaning, and toothbrush, rinse, and floss can’t reach deep enough to address the infection at home.
The Perio Tray™ by Perio Protect™ gently applies medication deep under the gums to fight the infections. You use it at home for just minutes each day. The tray is comfortable, flexible, and custom-fit precisely for your mouth.
Exploring the Potential of Dye-Free Doxycycline Topical Gel and Perio Gel™ with the Perio Protect Method™
ScriptWorks Pharmacy offers dye-free doxycycline topical gel paired with Perio Gel™ (Hydrogen Peroxide), compounded at 10 mg/ml. Perio Gel’s primary active ingredient is Hydrogen Peroxide which serves two roles. First and foremost, it kills bacteria. In addition, the bubbles from the hydrogen peroxide are releasing oxygen deep into the gum pockets. This creates a healthier environment for bacterial growth, so healthy bacteria can repopulate and exclude bad, pathogenic bacteria.
Doxycycline and Perio Gel™ may be used in conjunction with the Perio Protect Method™ — a non-invasive system that uses custom dental trays to deliver medicated gels deep below the gumline.
For patients managing chronic periodontal concerns, applying doxycycline gel directly to the affected areas using Perio Protect Trays may help maintain bacterial balance in the mouth. This targeted delivery system may support gum health by allowing the gel to remain in place for extended periods, which is often difficult to achieve through brushing or rinsing alone.
Video: Guide to Using the Perio Protect Tray System™
With Perio Tray™ therapy, you have a new chance against the infections. In additional to healthier gums, patients commonly report whiter teeth and fresher breath.
If you’ve been told that you have gum disease (gingivitis or periodontitis), ask your dentist if Perio Trays™ may be right for you.
If you have more questions about this product and its usage, feel free to ask our pharmacists.
Dentists and healthcare providers may recommend compounded doxycycline suspension or topical gel for managing oral health conditions such as periodontitis, post-surgical infections, and gingivitis.
Healthcare providers may prescribe doxycycline to address:
- Periodontitis
- Gingivitis
- Post-surgical dental infections
- Infections related to tooth extractions
- Other bacterial infections affecting oral tissues
Doxycycline Suspension Rx Order Form
We make it easy for California prescribers to get Doxycycline + Perio Gel™ and other compounded formulations for their patients.
Easily select from our recommended options to customize for each patient!
CA practitioners who may prescribe doxycycline for use with the Perio Protect Method™ dental tray-based systems:
- General Dentists (DDS, DMD) – primary prescribers for Perio Protect™ in routine dental care
- Periodontists – specialists in gum disease who frequently utilize Perio Protect™ trays and related therapies
- Oral and Maxillofacial Surgeons – may prescribe in post-operative care involving periodontal concerns
- Prosthodontists – when managing cases involving implants or prosthetic work with periodontal implications
Additional Support for Doxycycline Use with the Perio Protect Method™
Custom Tray Delivery as a Modern Approach
According to Dental Products Report, custom dental trays such as those used in the Perio Protect Method™ represent a shift in periodontal care. These trays enable deeper and potentially more sustained medication delivery below the gumline, reaching areas that traditional brushing and rinsing cannot access effectively.
Doxycycline as a Supportive Agent for Periodontal Conditions
A study by the Journal of Cellular Biotechnology highlights how tetracyclines — like doxycycline — have properties that may go beyond bacterial suppression. These compounds have been observed to exhibit anti-collagenase and anti-inflammatory effects, which may contribute to periodontal tissue support.
Evidence on Doxycycline + Peroxide Gel Combination
The Journal of Clinical Dentistry conducted a 6-month clinical study. It showed that the combination of peroxide gel and doxycycline, applied via custom trays, may support periodontal outcomes when used as an adjunct to scaling and root planing. The results suggested measurable clinical improvements in probing depths and plaque control.
Direct Delivery for Hard-to-Reach Cases
The Journal of Oral Biology and Dentistry discusses how direct medication delivery, such as via trays, may support management of peri-implantitis and mucositis. This aligns with the growing need for non-surgical adjuncts in patients with advanced or chronic periodontal conditions, including those with systemic comorbidities.
Hydrogen Peroxide as a Synergistic Agent
The Journal of Clinical Dentistry note that hydrogen peroxide may assist with subgingival biofilm disruption. When used in combination with antimicrobials like doxycycline, the peroxide may help clear biofilm pathways and enhance medication contact with the tissue.
Why a Dye-Free Formulation Matters
Many individuals experience sensitivities or allergic reactions to artificial dyes commonly found in commercial medications. A dye-free formulation eliminates this concern, reducing the risk of allergic reactions or gastrointestinal discomfort.
A dye-free version of doxycycline gel offers a clean, additive-free option for individuals with sensitivities to artificial dyes or preservatives. It also aligns with the goals of providers and patients seeking personalized, biocompatible dental solutions. By combining customized topical medication with Perio Protect’s delivery method, healthcare providers may support a more consistent and manageable approach to at-home periodontal care
Considerations for Healthcare Providers and Patients
When choosing a compounded medication, it is essential to work with a reputable pharmacy. ScriptWorks Pharmacy in California provides dye-free doxycycline suspension and gel to work with the Perio Protect Method™ to meet individual patient needs. Healthcare providers collaborate with ScriptWorks’ compounding pharmacists to determine the appropriate formulation based on a patient’s medical history and condition.
Proper administration and adherence to dosing guidelines are essential. Patients should follow their healthcare provider’s instructions carefully to help ensure the effectiveness of their medication. If any concerns arise regarding administration or potential side effects, we highly recommend consultation with a prescribing provider or pharmacist.
ScriptWorks: California’s Trusted Dental Compounding Pharmacy for Customized Medications
Patients and healthcare providers in California, especially around the Bay Area, looking for a reliable source of dye-free doxycycline suspension turn to ScriptWorks Pharmacy. By offering personalized formulations, we help ensure patients receive medications that align with their specific needs while prioritizing quality and safety. With the ability to customize medication concentrations and eliminate unnecessary additives, we support health providers in providing optimal care for patients in need of compounded solutions.
Why ScriptWorks?
Since 2003, the pharmacists and technicians at ScriptWorks have been formulating and preparing customized medicines for people and pets. We work closely with healthcare providers, veterinarians, and other medical professionals to develop customized medicine solutions.
We are a PCAB-accredited pharmacy, which means an independent board of auditors and inspectors has certified our procedures and policies in every aspect of compounding. Learn more about PCAB accreditation here.
References:
Cochrane, B. (2013). “In a generation, trays are going to change the face of dentistry”: one clinician’s view on the Perio Protect Method and Perio Trays. DPR. Link
Dunlap T. (2016). Prescribing hydrogen peroxide in the treatment of periodontal disease. Oral Health, 64-68. Link
Dunlap, T., Keller, D., Marshall, M., Costerton, J., Schaudinn, C., Sindelar, B., & Cotton, J. (2011). Subgingival delivery of oral debriding agents: a proof of concept. The Journal of Clinical Dentistry, 22(5), 149-158. Link
Fraser, G. (2018). Treating periodontal disease with perio protect: Catapult Education members evaluate this gum disease treatment device. DPR, 90-91. Link
Keller, D., Buechel, M., Goldstein, J., Sawyer, G., & Dunlap T. (2017). Managing peri-implantitis and peri-mucositis with direct medication delivery. Int J Dent & Oral Heal, 103-116. Link
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Keller, D.C. & Buechel, M. (2017). Direct medication delivery modifies the periodontal biofilm. Oral Biol Dent, 1. Link
Marshall, M., Cancro, L., & Fischman, L. (1995). Hydrogen peroxide: a review of its use in Dentistry. J Periodontol, 66(9), 786-96. Link
Putt, M., Mallatt, M., Messmann, L., & Proskin, H. (2014). A 6-month clinical investigation of custom tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planning for treatment of periodontitis. American Journal of Dentistry, 27, 273-284. Link
Putt, M. & Proskin, H. (2013). Custom tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: a randomized, controlled three-month clinical trial. The Journal of Clinical Dentistry, 24,100-107. Link
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Xing, R., Witsø, I. L., Jugowiec, D., Tiainen, H., Shabestari, M., Lyngstadaas, S. P., … & Haugen, H. J. (2015). Antibacterial effect of doxycycline-coated dental abutment surfaces. Biomedical Materials, 10(5), 055003. Link